Publication | Language: EN | Total Time: 20m
This publication examines the impact of using an amino acid formula containing pre- and probiotics (synbiotics) in infants with cow's milk protein allergy (CMPA). The retrospective matched cohort study analyzed data from The Health Improvement Network database, comparing 148 infants prescribed either AAF-Syn (containing probiotic Bifidobacterium breve M16-V and prebiotics) or AAF without synbiotics.
The study found that AAF-Syn was associated with significant reductions in symptoms, infections, medication prescriptions, and healthcare contacts compared to AAF. Infants prescribed AAF-Syn had a higher probability of achieving asymptomatic management without hypoallergenic formula and a shorter clinical course of symptoms. AAF-Syn was also associated with potential cost-savings per infant over the clinical course of symptoms.
The study provides evidence consistent with clinical trials, suggesting that AAF-Syn may offer clinical and healthcare benefits with potential economic impact, possibly due to its effect on the gut microbiome. Further research is needed to explore this relationship.
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